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You could set the virtual env via:

$ python3 -m venv venv
$ source venv/bin/activate
$ pip3 install -r requirements.txt

as per the readme in azure-py-appservice. The appservice settings are also set there. Here is how you could do it:

const app = new web.WebApp("fa", {
    resourceGroupName: resourceGroup.name,
    name: "myuniqueapp",
    location: resourceGroup.location,
    serverFarmId: plan.id,
    kind: "functionapp",
    siteConfig: {
        appSettings: [
            { name: "AzureWebJobsStorage", value: storageConnectionString },            
            { name: "FUNCTIONS_EXTENSION_VERSION", value: "~3" },            
            { name: "FUNCTIONS_WORKER_RUNTIME", value: "node" },
            { name: "WEBSITE_NODE_DEFAULT_VERSION", value: "10.14.1" },
            { name: "WEBSITE_RUN_FROM_PACKAGE", value: "<https://mikhailworkshop.blob.core.windows.net/zips/app.zip>" },
        ]    
    },
});

I work with venv locally (macOS), but I am using a Linux AppServicePlan. So in case of native dependencies, it won't work. I would like to deploy only my code (

requirements.txt

and

main.py

) and have Azure do

python3 -m venv venv; source ...

on each deployment.