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programmatically in typescript how to handle this.

When you say "programatically", do you mean from within a Pulumi program or you want to write a script/app that will just go and clear locks?

At run time, before I start an operation on a stack, can I clean up locks if present on that particular stack  via pulumi cancel in my code and then let stack.up be called ?

If you're using our <https://www.pulumi.com/docs/iac/automation-api/getting-started-automation-api/|Automation api> then yes before you run `stack.up()` you can cancel, but be aware that this may leave the stack in an inconsistent state if a resource operation was pending when the update was canceled.